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What are the steps involved in performing a retrosynthesis of complex organic molecules, and how can one identify suitable disconnections for simplification?

Answer 1

Michelle Hunter

Retrosynthesis involves breaking down a complex molecule into simpler precursors. Steps include identifying functional groups, strategic bonds to break (disconnections), and using known reactions to simplify the structure. Suitable disconnections are identified by considering stability, functional group compatibility, and synthetic feasibility.